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Journal article

Inhibition of heterologous strains of HIV by antisense RNA.

Abstract:

Antisense RNA can inhibit the expression of messenger RNAs (mRNAs) to which they are complementary by a variety of mechanisms and might provide the basis for antiviral therapies of high selectivity. In a previous study of six retrovirally expressed antisense RNAs targeted to HIV-1IIIB, we found that two significantly reduced HIV-1IIIB replication. Here we test the degree to which this inhibitory effect tolerates the natural variation found in the nucleotide sequence of different strains of HI...

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Publication status:
Published

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Journal:
AIDS (London, England)
Volume:
5
Issue:
2
Pages:
145-151
Publication date:
1991-02-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Source identifiers:
25694
Language:
English
Keywords:
Pubs id:
pubs:25694
UUID:
uuid:fe99b9f5-5916-4b18-86ec-901a748327ca
Local pid:
pubs:25694
Deposit date:
2012-12-19

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