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Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge

Abstract:

Introduction

Drugs that prolong the QT interval on the electrocardiogram present a major safety concern for pharmaceutical companies and regulatory agencies. Despite a range of assays performed to assess compound effects on the QT interval, QTprolongation remains a major cause of attrition during compound development. In silico assays could alleviate such problems. In this study we evaluated an in silico method of predicting the results of a rabbit left-ventricular wedge assay.

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Publisher copy:
10.1016/j.vascn.2013.04.004

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Journal:
Journal of Pharmacological and Toxicological Methods More from this journal
Volume:
68
Issue:
1
Pages:
88-96
Publication date:
2013-01-01
DOI:
UUID:
uuid:fe986028-f704-4b66-b96d-acd5b0c80a8b
Local pid:
cs:6842
Deposit date:
2015-03-31

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