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Thesis

Targeting the mevalonate pathway for pharmacological intervention

Abstract:

Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway and the main molecular target of nitrogen-containing bisphosphonates (N-BPs), potent inhibitors of osteoclastic activity and the leading drug of choice for conditions characterized by excessive bone resorption. The main aim of this thesis is to investigate the interaction of N-BPs with FPPS in order to gain further insights into the mechanism of drug inhibition. Kinetic and crystallographic studies f...

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Institution:
University of Oxford
Oxford college:
Green Templeton College
Department:
Medical Sciences Division - Orthopaedic Surgery

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:fe945074-e645-4c1d-9598-e28b51a43cca
Local pid:
ora:5723

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