Journal article icon

Journal article

The effect of iron availability on transcription of the Neisseria meningitidis fHbp gene varies among clonal complexes

Abstract:

Factor H binding protein (fHbp) is a major antigenic component of novel vaccines designed to protect against meningococcal disease. Prediction of the potential coverage of these vaccines is difficult, as fHbp is antigenically variable and levels of expression differ among isolates. Transcriptional regulation of the fHbp gene is poorly understood, although evidence suggests that oxygen availability is involved. In this study iron accessibility was found to affect fHbp transcription. However, r...

Expand abstract

Actions


Access Document


Publisher copy:
10.1099/mic.0.054957-0

Authors


Sanders, H More by this author
Brehony, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Feavers, IM More by this author
Journal:
Microbiology
Volume:
158
Issue:
4
Pages:
869-876
Publication date:
2012-04-05
DOI:
ISSN:
1350-0872
URN:
uuid:fe87aec3-312d-4a89-88c2-96217ac94344
Source identifiers:
323288
Local pid:
pubs:323288
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP