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Treating breathlessness via the brain: changes in brain activity over a course of pulmonary rehabilitation

Abstract:

Background. Breathlessness in chronic obstructive pulmonary disease (COPD) is often discordant with airway pathophysiology ("over-perception"). Pulmonary rehabilitation profoundly affects breathlessness, without influencing lung function. Learned associations influence brain mechanisms of sensory perception. We hypothesised that improvements in breathlessness with pulmonary rehabilitation may be explained by changing neural representations of learned associations.

Methods. In 31 p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1183/13993003.01029-2017

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
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Medical Research Council More from this funder
National Institute for Health Research More from this funder
Publisher:
European Respiratory Society Publisher's website
Journal:
European Respiratory Journal Journal website
Volume:
50
Issue:
3
Pages:
1701029
Publication date:
2017-09-12
Acceptance date:
2017-06-17
DOI:
EISSN:
1399-3003
ISSN:
0903-1936
Pubs id:
pubs:702014
URN:
uri:fe808eb0-b8b1-441e-8c69-e5ee1b117ecc
UUID:
uuid:fe808eb0-b8b1-441e-8c69-e5ee1b117ecc
Local pid:
pubs:702014
Paper number:
3

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