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Development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries

Abstract:

Current pediatric antibiotic therapies often use oral and parenteral routes of administration. Neither are suitable for treating very sick neonates who cannot take oral medication and may be several hours away from hospital in developing countries. Here, we report on the development of rectal forms of ceftriaxone, a third-generation cephalosporin. Rectodispersible tablets and capsules were developed and successfully passed 6-month accelerated stability tests. Rabbit bioavailability showed pla...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.xphs.2019.03.004

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Publisher:
Elsevier Publisher's website
Journal:
Journal of Pharmaceutical Sciences Journal website
Volume:
108
Issue:
8
Pages:
2805-2813
Publication date:
2019-03-13
Acceptance date:
2019-03-06
DOI:
EISSN:
1520-6017
ISSN:
0022-3549
Pubs id:
pubs:996261
URN:
uri:fe7cc5dd-2c5f-4ddf-b98c-0761ba492579
UUID:
uuid:fe7cc5dd-2c5f-4ddf-b98c-0761ba492579
Local pid:
pubs:996261

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