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Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid

Abstract:

Proliferation and invasion of cancer cells require favorable pH, yet potentially toxic quantities of acid are produced metabolically. Membrane-bound transporters extrude acid from cancer cells, but little is known about the mechanisms that handle acid once it is released into the poorly-perfused extracellular space. Here, we studied acid-handling by stromal myofibroblasts (colon cancer-derived Hs675.T, intestinal InMyoFib, embryonic colon-derived CCD-112-CoN), skin fibroblasts (NHDFAd) and co...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1610954113

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Funding agency for:
Bodmer, W
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Publication date:
2016-08-19
DOI:
ISSN:
1091-6490
URN:
uuid:fe7741e6-b793-4a78-b1dc-0f6bd63d64fe
Source identifiers:
635169
Local pid:
pubs:635169

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