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Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn

Abstract:

Excitatory interneurons account for the majority of neurons in the superficial dorsal horn, but despite their presumed contribution to pain and itch, there is still limited information about their organisation and function. We recently identified 2 populations of excitatory interneuron defined by expression of gastrin-releasing peptide (GRP) or substance P (SP). Here, we demonstrate that these cells show major differences in their morphological, electrophysiological, and pharmacological prope...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1097/j.pain.0000000000001406

Authors


Dickie, AC More by this author
Iwagaki, N More by this author
Polgár, E More by this author
Gutierrez-Mecinas, M More by this author
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Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
Pain Journal website
Volume:
160
Issue:
2
Pages:
442–462
Publication date:
2018-09-20
Acceptance date:
2018-09-05
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
Pubs id:
pubs:923318
URN:
uri:fe77283f-fed9-4329-a335-ff59cf1f5275
UUID:
uuid:fe77283f-fed9-4329-a335-ff59cf1f5275
Local pid:
pubs:923318

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