- Abstract:
-
T cell activation is mediated by microclusters (MCs) containing T cell receptors (TCRs), kinases, and adaptors. Although TCR MCs translocate to form a central supramolecular activation cluster (cSMAC) of the immunological synapse at the interface of a T cell and an antigen-presenting cell, the role of MC translocation in T cell signaling remains unclear. Here, we found that the accumulation of MCs at cSMAC was important for T cell costimulation. Costimulatory receptor CD28 was initially recru...
Expand abstract - Publisher copy:
- 10.1016/j.immuni.2008.08.011
-
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- Journal:
- Immunity
- Volume:
- 29
- Issue:
- 4
- Pages:
- 589-601
- Publication date:
- 2008-10-05
- DOI:
- EISSN:
-
1097-4180
- ISSN:
-
1074-7613
- URN:
-
uuid:fe6c33ac-c894-4374-bf91-69c0699b6add
- Source identifiers:
-
426307
- Local pid:
- pubs:426307
- Copyright date:
- 2008
Journal article
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.
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