Journal article icon

Journal article

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.

Abstract:

T cell activation is mediated by microclusters (MCs) containing T cell receptors (TCRs), kinases, and adaptors. Although TCR MCs translocate to form a central supramolecular activation cluster (cSMAC) of the immunological synapse at the interface of a T cell and an antigen-presenting cell, the role of MC translocation in T cell signaling remains unclear. Here, we found that the accumulation of MCs at cSMAC was important for T cell costimulation. Costimulatory receptor CD28 was initially recru...

Expand abstract

Actions


Access Document


Authors


Expand authors...
Journal:
Immunity
Volume:
29
Issue:
4
Pages:
589-601
Publication date:
2008-10-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:fe6c33ac-c894-4374-bf91-69c0699b6add
Source identifiers:
426307
Local pid:
pubs:426307

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP