Journal article icon

Journal article

Cytotoxic T-lymphocyte escape mutations identified by HLA association favor those which escape and revert rapidly.

Abstract:

Identifying human immunodeficiency virus (HIV) immune escape mutations has implications for understanding the impact of host immunity on pathogen evolution and guiding the choice of vaccine antigens. One means of identifying cytotoxic-T-lymphocyte (CTL) escape mutations is to search for statistical associations between mutations and host human leukocyte antigen (HLA) class I alleles at the population level. The impact of evolutionary rates on the strength of such associations is not well defi...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/jvi.07020-11

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Expand authors...
Journal:
Journal of virology
Volume:
86
Issue:
16
Pages:
8568-8580
Publication date:
2012-08-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:fe628704-466c-41da-be00-3c44390b9739
Source identifiers:
334698
Local pid:
pubs:334698

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP