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Journal article

Cytotoxic T-lymphocyte escape mutations identified by HLA association favor those which escape and revert rapidly.

Abstract:

Identifying human immunodeficiency virus (HIV) immune escape mutations has implications for understanding the impact of host immunity on pathogen evolution and guiding the choice of vaccine antigens. One means of identifying cytotoxic-T-lymphocyte (CTL) escape mutations is to search for statistical associations between mutations and host human leukocyte antigen (HLA) class I alleles at the population level. The impact of evolutionary rates on the strength of such associations is not well defi...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.07020-11

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Journal of virology More from this journal
Volume:
86
Issue:
16
Pages:
8568-8580
Publication date:
2012-08-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:334698
UUID:
uuid:fe628704-466c-41da-be00-3c44390b9739
Local pid:
pubs:334698
Source identifiers:
334698
Deposit date:
2013-11-16

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