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Journal article

Sequestration and microvascular congestion are associated with coma in human cerebral malaria.

Abstract:

The pathogenesis of coma in severe Plasmodium falciparum malaria remains poorly understood. Obstruction of the brain microvasculature because of sequestration of parasitized red blood cells (pRBCs) represents one mechanism that could contribute to coma in cerebral malaria. Quantitative postmortem microscopy of brain sections from Vietnamese adults dying of malaria confirmed that sequestration in the cerebral microvasculature was significantly higher in patients with cerebral malaria (CM; n = ...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jir812

Authors


Ponsford, MJ More by this author
Medana, IM More by this author
Prapansilp, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Journal:
The Journal of infectious diseases
Volume:
205
Issue:
4
Pages:
663-671
Publication date:
2012-02-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:fe600624-a964-420c-9d7b-ea2c3153e7de
Source identifiers:
342858
Local pid:
pubs:342858

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