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Modelling the impact of clot fragmentation on the microcirculation after thrombectomy

Abstract:

Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy) do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this ‘no-reperfusion’ phenomenon is micro-emboli fragmenting off the large clot during thrombectomy and occluding smaller blood vessels downstream of the clot location. This is impossible to observe in-vivo and so we here develop an in-silico model based on in-vitro experiments to model the effect of micro-emboli on b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1008515

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
ORCID:
0000-0002-2732-5927
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
ORCID:
0000-0003-3246-9826
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
ORCID:
0000-0002-5082-0299
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
ORCID:
0000-0003-1156-2810
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Name:
European Commission
Grant:
777072
Publisher:
Public Library of Science
Journal:
PLoS Computational Biology More from this journal
Volume:
17
Issue:
3
Article number:
e1008515
Publication date:
2021-03-12
Acceptance date:
2021-02-23
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Language:
English
Keywords:
Pubs id:
1167943
Local pid:
pubs:1167943
Deposit date:
2021-03-25

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