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Levamisole inhibits sequestration of infected red blood cells in patients with falciparum malaria.

Abstract:

BACKGROUND: Sequestration of infected red blood cells (iRBCs) in the microcirculation is central to the pathophysiology of falciparum malaria. It is caused by cytoadhesion of iRBCs to vascular endothelium, mediated through the binding of Plasmodium falciparum erythrocyte membrane protein-1 to several endothelial receptors. Binding to CD36, the major vascular receptor, is stabilized through dephosphorylation of CD36 by an alkaline phosphatase. This is inhibited by the alkaline phosphatase-inh...

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Publication status:
Published

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Publisher copy:
10.1086/519287

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Silamut, K More by this author
Charunwatthana, P More by this author
Chuasuwanchai, S More by this author
Ruangveerayut, R More by this author
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Journal:
The Journal of infectious diseases
Volume:
196
Issue:
3
Pages:
460-466
Publication date:
2007-08-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:fe5d47f8-bf0a-44bb-9a15-b4235e6ba967
Source identifiers:
33907
Local pid:
pubs:33907

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