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Journal article

Pharmacokinetic properties of anti-influenza neuraminidase inhibitors.

Abstract:

Neuraminidase inhibitors are the mainstay of anti-influenza treatment. Oseltamivir is the most widely used drug but is currently available only as an oral formulation. Resistance spreads rapidly in seasonal H1N1 influenza A viruses, which were universally resistant in 2008, because of the H275Y mutation in the neuraminidase (NA) gene. Oseltamivir is a prodrug for the active carboxylate metabolite. Ex vivo conversion in blood samples may have confounded early pharmacokinetic studies. Oseltamiv...

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Publisher copy:
10.1177/0091270012440280

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Journal of clinical pharmacology More from this journal
Volume:
53
Issue:
2
Pages:
119-139
Publication date:
2013-02-01
DOI:
EISSN:
1552-4604
ISSN:
0091-2700
Language:
English
Keywords:
Pubs id:
pubs:387099
UUID:
uuid:fe5b3f8f-8959-47e5-a078-cb09686bb8e0
Local pid:
pubs:387099
Source identifiers:
387099
Deposit date:
2013-11-17

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