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Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria.

Abstract:

Extracellular release of granzymes is considered to reflect the involvement of cytotoxic T lymphocytes and NK cells in various disease states. To obtain insight into granzyme release during bacterial infection, granzyme levels were measured during experimental human endotoxemia and in patients with melioidosis, a severe infection due to gram-negative bacteria. Plasma concentrations of granzyme A (GrA) and GrB increased transiently after endotoxin administration, peaking after 2-6 h. In patien...

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Publication status:
Published

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Publisher copy:
10.1086/315642

Authors


Simpson, AJ More by this author
Wolbink, AM More by this author
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Journal:
The Journal of infectious diseases
Volume:
182
Issue:
1
Pages:
206-213
Publication date:
2000-07-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:fe45bbe3-bcbc-4a86-84a6-cacb0103bd58
Source identifiers:
37544
Local pid:
pubs:37544

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