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Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa

Abstract:

Hypertrophic cardiomyopathy (HCM) affects up to 1 in 500 of the population and is the commonest cause of sudden death in the younger population. However, its pathophysiology and mechanisms of progression are not fully understood. The underlying sarcomere mutations increase the energy cost of contraction, and impaired resting energetics (i.e. phosphocreatine/adenosine triphosphate, PCr/ATP, as measured by 31Phosphorus MR Spectroscopy, 31P MRS) has been documented in genetically modified animal...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Suttie, JJ More by this author
Holloway, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
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Publisher:
American Heart Association Publisher's website
Volume:
124
Issue:
21
Pages:
A15324
Publication date:
2015-12-05
ISSN:
0009-7322
URN:
uuid:fe3cd738-ba00-4a14-a225-f2b3fb62711d
Source identifiers:
317120
Local pid:
pubs:317120

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