Conference item icon

Conference item

Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa

Abstract:

Hypertrophic cardiomyopathy (HCM) affects up to 1 in 500 of the population and is the commonest cause of sudden death in the younger population. However, its pathophysiology and mechanisms of progression are not fully understood. The underlying sarcomere mutations increase the energy cost of contraction, and impaired resting energetics (i.e. phosphocreatine/adenosine triphosphate, PCr/ATP, as measured by 31Phosphorus MR Spectroscopy, 31P MRS) has been documented in genetically modified animal...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Publisher:
American Heart Association
Host title:
Circulation
Journal:
Circulation More from this journal
Volume:
124
Issue:
21
Pages:
A15324
Publication date:
2015-12-01
ISSN:
0009-7322
Keywords:
Pubs id:
pubs:317120
UUID:
uuid:fe3cd738-ba00-4a14-a225-f2b3fb62711d
Local pid:
pubs:317120
Source identifiers:
317120
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP