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Journal article

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

Abstract:

The immunological synapse formed between a T‐cell and an antigen‐presenting cell is important for cell–cell communication during T‐cell‐mediated immune responses. Immunological synapse formation begins with stimulation of the T‐cell receptor (TCR). TCR microclusters are assembled and transported to the center of the immunological synapse in an actin polymerization‐dependent process. However, the physical link between TCR and actin remains elusive. Here we show that lymphocyte‐specific Crk‐ass...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/icb.2016.61

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More from this funder
Name:
National Institutes of Health
Grant:
R01 AI088106-01A1
More from this funder
Name:
Wellcome Trust
Funding agency for:
Dustin, M
More from this funder
Name:
Kennedy Institute of Rheumatology Trust
Funding agency for:
Dustin, M
Publisher:
Nature Publishing Group
Journal:
Immunology and Cell Biology More from this journal
Volume:
94
Issue:
10
Pages:
981–993
Publication date:
2016-11-01
Acceptance date:
2016-06-20
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Pmid:
27359298
Language:
English
Keywords:
Pubs id:
pubs:634207
UUID:
uuid:fe2c3c05-5d52-45db-a790-9660422e0e1a
Local pid:
pubs:634207
Source identifiers:
634207
Deposit date:
2016-11-03

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