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Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.

Abstract:

BACKGROUND: Group II metabotropic glutamate receptors (mGlu2 and mGlu3, encoded by Grm2 and Grm3) have been the focus of attention as treatment targets for a number of psychiatric conditions. Double knockout mice lacking mGlu2 and mGlu3 (mGlu2/3-/-) show a subtle behavioural phenotype, being hypoactive under basal conditions and in response to amphetamine, and with a spatial memory deficit that depends on the arousal properties of the task. The neurochemical correlates of this profile are unk...

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Publisher copy:
10.1186/1471-2202-14-102

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
BMC neuroscience
Volume:
14
Issue:
1
Pages:
102
Publication date:
2013-01-01
DOI:
EISSN:
1471-2202
ISSN:
1471-2202
URN:
uuid:fe2950bd-cb73-4bb4-be4f-279ecabba33b
Source identifiers:
431026
Local pid:
pubs:431026

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