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Doxycycline alters the porcine renal proteome and degradome during hypothermic machine perfusion

Abstract:

Ischemia-reperfusion injury (IRI) is a hallmark for tissue injury in donation after circulatory death (DCD) kidneys. The implementation of hypothermic machine perfusion (HMP) provides a platform for improved preservation of DCD kidneys. Doxycycline administration has shown protective effects during IRI. Therefore, we explored the impact of doxycycline on proteolytic degradation mechanisms and the urinary proteome of perfused kidney grafts. Porcine kidneys underwent 30 min of warm ischemia, 24...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/cimb44020039

Authors


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Role:
Author
ORCID:
0000-0003-4666-2993
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Role:
Author
ORCID:
0000-0001-5556-6632
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-8160-2446
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Name:
Medical Research Council
Grant:
MR/R014132/1
Publisher:
MDPI
Journal:
Current Issues in Molecular Biology More from this journal
Volume:
44
Issue:
2
Pages:
559-577
Publication date:
2022-01-23
Acceptance date:
2022-01-19
DOI:
EISSN:
1467-3045
ISSN:
1467-3037
Language:
English
Keywords:
Pubs id:
1234890
Local pid:
pubs:1234890
Deposit date:
2022-01-27

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