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Journal article

Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy.

Abstract:

TDP43 protein mislocalization is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia, and mutations in the gene encoding TDP43 cause both disorders, further highlighting its role in disease pathogenesis. TDP43 is a heterogenous ribonucleoprotein, therefore suggesting that alterations in RNA metabolism play a role in these disorders, although direct evidence in patients is lacking. Sporadic inclusion body myositis (sIBM) is the most common acq...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Neurobiology of aging
Volume:
35
Issue:
6
Pages:
1491-1498
Publication date:
2014-06-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:fe1d6d92-6a3d-4d82-be8a-f3ced8d2442b
Source identifiers:
465650
Local pid:
pubs:465650

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