Journal article
Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy.
- Abstract:
-
TDP43 protein mislocalization is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia, and mutations in the gene encoding TDP43 cause both disorders, further highlighting its role in disease pathogenesis. TDP43 is a heterogenous ribonucleoprotein, therefore suggesting that alterations in RNA metabolism play a role in these disorders, although direct evidence in patients is lacking. Sporadic inclusion body myositis (sIBM) is the most common acq...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.neurobiolaging.2013.12.029
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Bibliographic Details
- Journal:
- Neurobiology of aging
- Volume:
- 35
- Issue:
- 6
- Pages:
- 1491-1498
- Publication date:
- 2014-06-01
- DOI:
- EISSN:
-
1558-1497
- ISSN:
-
0197-4580
- Source identifiers:
-
465650
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:465650
- UUID:
-
uuid:fe1d6d92-6a3d-4d82-be8a-f3ced8d2442b
- Local pid:
- pubs:465650
- Deposit date:
- 2014-06-16
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- Copyright date:
- 2014
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