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Journal article

Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy.

Abstract:

With increasing interest in treating osteoarthritis at its earliest stages, it has become important to understand the mechanisms by which the disease progresses across a joint. Here, second harmonic generation (SHG) microscopy, coupled with a two-dimensional spring-mass network model, was used to image and investigate the collagen meshwork architecture at the cartilage surface surrounding osteoarthritic lesions. We found that minor weakening of the collagen meshwork leads to the bundling of f...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmbbm.2011.08.004

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Légaré, F More by this author
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Journal:
Journal of the mechanical behavior of biomedical materials
Volume:
5
Issue:
1
Pages:
62-70
Publication date:
2012-01-05
DOI:
EISSN:
1878-0180
ISSN:
1751-6161
URN:
uuid:fe1ca9dc-388c-4aab-9a78-a1ebd8de887f
Source identifiers:
206054
Local pid:
pubs:206054

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