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Cancer-associated fibroblasts promote proliferation of endometrial cancer cells

Abstract:

Endometrial cancer is the most commonly diagnosed gynecologic malignancy worldwide; yet the tumor microenvironment, especially the fibroblast cells surrounding the cancer cells, is poorly understood. We established four primary cultures of fibroblasts from human endometrial cancer tissues (cancer-associated fibroblasts, CAFs) using antibody-conjugated magnetic bead isolation. These relatively homogenous fibroblast cultures expressed fibroblast markers (CD90, vimentin and alpha-smooth muscle a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0068923

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
8
Issue:
7
Pages:
e68923
Publication date:
2013-07-26
Acceptance date:
2013-06-03
DOI:
ISSN:
1932-6203
Source identifiers:
747118

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