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Proline-induced hinges in transmembrane helices: possible roles in ion channel gating.

Abstract:

A number of ion channels contain transmembrane (TM) alpha-helices that contain proline-induced molecular hinges. These TM helices include the channel-forming peptide alamethicin (Alm), the S6 helix from voltage-gated potassium (Kv) channels, and the D5 helix from voltage-gated chloride (CLC) channels. For both Alm and KvS6, experimental data implicate hinge-bending motions of the helix in an aspect of channel gating. We have compared the hinge-bending motions of these TM helices in bilayer-li...

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Publication status:
Published

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Publisher copy:
10.1002/prot.1073

Authors


Tieleman, DP More by this author
Shrivastava, IH More by this author
Ulmschneider, MR More by this author
Sansom, MS More by this author
Journal:
Proteins
Volume:
44
Issue:
2
Pages:
63-72
Publication date:
2001-08-05
DOI:
EISSN:
1097-0134
ISSN:
0887-3585
URN:
uuid:fe16aad3-36ab-4abc-9ead-811c0c1aeb35
Source identifiers:
100645
Local pid:
pubs:100645

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