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The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration.

Abstract:

Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cell growth, resistance to apoptosis, and changes in morphology and migration of transformed cells. To search for new NPM-ALK interacting molecules, we developed a mass spectrometry...

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Publication status:
Published

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Authors


Ambrogio, C More by this author
Boeri Erba, E More by this author
Boccalatte, F More by this author
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Journal:
Cancer research
Volume:
67
Issue:
9
Pages:
4278-4286
Publication date:
2007-05-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:fe135d1a-c6df-496a-9f64-fb85a1131710
Source identifiers:
384641
Local pid:
pubs:384641

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