- Abstract:
-
Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cell growth, resistance to apoptosis, and changes in morphology and migration of transformed cells. To search for new NPM-ALK interacting molecules, we developed a mass spectrometry...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1158/0008-5472.can-06-4350
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- Journal:
- Cancer research
- Volume:
- 67
- Issue:
- 9
- Pages:
- 4278-4286
- Publication date:
- 2007-05-05
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- URN:
-
uuid:fe135d1a-c6df-496a-9f64-fb85a1131710
- Source identifiers:
-
384641
- Local pid:
- pubs:384641
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration.
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