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Accuracy and reproducibility of protein-DNA microarray technology

Abstract:

Microarray-based methods for understanding protein-DNA interactions have been developed in the last 6 years due to the need to introduce high-throughput technologies in this field. Protein-DNA microarrays utilise chips upon which a large number of DNA sequences may be printed or synthesised. Any DNA-binding protein may then be interrogated by applying either purified sample or cellular/nuclear extracts, subject to availability of a suitable detection system. Protein is simply added to the mic...

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Publisher copy:
10.1007/10_2006_035

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Ragoussis, J More by this author
Journal:
Advances in Biochemical Engineering/Biotechnology
Volume:
104
Pages:
87-110
Publication date:
2006
DOI:
ISSN:
0724-6145
URN:
uuid:fe09c3ad-a6a0-46ff-bf52-1fbc3a394059
Source identifiers:
95168
Local pid:
pubs:95168

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