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Journal article

Beta-cell function improved by supplementing basal insulin secretion in mild diabetes.

Abstract:

Insulin supplements, predominantly as a constant basal fish insulin infusion, were given to patients with mild diabetes to reduce the overnight fasting glucose level to normal. The basal plasma human insulin levels were reduced to subnormal levels by the infusion, and the insulin response to intravenous glucose was enhanced. The beta-cell in diabetes seems to be in a vicious circle in which an impaired insulin response to glucose produces hyperglycaemia, which stresses beta-cell function, mak...

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Publication status:
Published

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Publisher copy:
10.1136/bmj.1.6020.1252

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
Role:
Author
Journal:
British medical journal
Volume:
1
Issue:
6020
Pages:
1252-1254
Publication date:
1976-05-05
DOI:
EISSN:
1468-5833
ISSN:
0007-1447
URN:
uuid:fe092e41-36d5-4197-8dc9-f5ff28dd6f67
Source identifiers:
11511
Local pid:
pubs:11511

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