Journal article icon

Journal article

Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human peripheral blood mononuclear cells

Abstract:

A major challenge to TB vaccine development is the lack of a validated immune correlate of protection. Mycobacterial growth inhibition assays (MGIAs) represent an unbiased measure of the ability to control mycobacterial growth in vitro. A successful MGIA could be applied to preclinical and clinical post-vaccination samples to aid in the selection of novel vaccine candidates at an early stage and provide a relevant measure of immunogenicity and protection. However, assay harmonisation is criti...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.jim.2019.01.006

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
Oxford college:
Somerville College
Van Meijgaarden, KE More by this author
Giannoni, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
Expand authors...
More from this funder
Grant:
084785/Z/08/Z Milestone
Publisher:
Elsevier Publisher's website
Journal:
Journal of Immunological Methods Journal website
Volume:
469
Pages:
1-10
Publication date:
2019-01-31
Acceptance date:
2019-01-15
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
Pubs id:
pubs:969344
URN:
uri:fe0188e8-8cae-4b6c-89a9-eed687c394a9
UUID:
uuid:fe0188e8-8cae-4b6c-89a9-eed687c394a9
Local pid:
pubs:969344

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP