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Journal article

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.

Abstract:

Base excision repair (BER) is the major pathway for processing of simple lesions in DNA, including single-strand breaks, base damage, and base loss. The scaffold protein XRCC1, DNA polymerase beta, and DNA ligase IIIalpha play pivotal roles in BER. Although all these enzymes are essential for development, their cellular levels must be tightly regulated because increased amounts of BER enzymes lead to elevated mutagenesis and genetic instability and are frequently found in cancer cells. Here w...

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Publication status:
Published

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Journal:
Molecular cell More from this journal
Volume:
29
Issue:
4
Pages:
477-487
Publication date:
2008-02-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Language:
English
Keywords:
Pubs id:
pubs:131340
UUID:
uuid:fdf9ba2e-2dcc-4f7d-adb3-f1741eebbb8c
Local pid:
pubs:131340
Source identifiers:
131340
Deposit date:
2012-12-19

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