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Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition.

Abstract:

Methanogenic archaea possess unusual seryl-tRNA synthetase (SerRS), evolutionarily distinct from the SerRSs found in other archaea, eucaryotes and bacteria. The two types of SerRSs show only minimal sequence similarity, primarily within class II conserved motifs 1, 2 and 3. Here, we report a 2.5 A resolution crystal structure of the atypical methanogenic Methanosarcina barkeri SerRS and its complexes with ATP, serine and the nonhydrolysable seryl-adenylate analogue 5'-O-(N-serylsulfamoyl)aden...

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Publisher copy:
10.1038/sj.emboj.7601129

Authors


Bilokapic, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Gruic-Sovulj, I More by this author
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Journal:
The EMBO journal
Volume:
25
Issue:
11
Pages:
2498-2509
Publication date:
2006-06-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:fdf935c8-06e0-4e36-bd83-8a5c5d704631
Source identifiers:
376188
Local pid:
pubs:376188

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