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Thesis

Real-time single-molecule observations of conformational changes in DNA polymerase

Abstract:

Genetic information is encoded in the long sequence of bases which form DNA, which is replicated during cell division by enzymes known as DNA Polymerases. Polymerases replicate DNA extremely accurately to avoid errors which can cause cell death and diseases such as cancer, although the mechanisms behind these extraordinary fidelities are not well understood.

A large conformational change in the protein, in which the “fingers" subdomain closes around an incoming nucleotide, is though...

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Institution:
University of Oxford
Research group:
KAPANIDIS GROUP
Oxford college:
University College
Department:
Mathematical,Physical & Life Sciences Division - Physics - Condensed Matter Physics

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:fdf11b59-2e58-4174-9219-9d61e4528f65
Local pid:
ora:11507

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