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Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites

Abstract:

Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR and PfRH5 is essential for erythrocyte invasion, mediated by the interaction between PfRH5 and erythrocyte receptor basigin (BSG). However, whilst CyRPA and RIPR are present in most Plasmodium species, RH5 is found only in the small Laverania subgenus....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1007809

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Role:
Author
ORCID:
0000-0003-1188-668X
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Name:
Wellcome Trust
Grant:
101020/Z/13/Z
Publisher:
Public Library of Science
Journal:
PLoS Pathogens More from this journal
Volume:
15
Issue:
6
Article number:
e1007809
Publication date:
2019-06-11
Acceptance date:
2019-05-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
31185066
Language:
English
Pubs id:
pubs:1014155
UUID:
uuid:fde7887a-e541-4a3c-9eff-62b573558b26
Local pid:
pubs:1014155
Source identifiers:
1014155
Deposit date:
2019-06-17

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