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Drug-induced purposeless chewing: animal model of dyskinesia or nausea?

Abstract:

Drug-induced purposeless chewing movements in rodents are often considered to represent movement disorders or dyskinesias. We have compared the ability of drugs to induce chewing and retching or emesis in squirrel monkeys; such studies are not possible in rodents, which do not vomit. Acute administration of oxotremorine (3.3-33 micrograms/kg IM), SKF38393 (1-30 mg/kg SC) or ipecacuanha (0.5-0.75 mg/kg PO) caused dose-related increases in purposeless chewing which was frequently associated wit...

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Publication status:
Published

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Publisher copy:
10.1007/bf02244098

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Psychopharmacology More from this journal
Volume:
102
Issue:
3
Pages:
325-328
Publication date:
1990-01-01
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Language:
English
Keywords:
Pubs id:
pubs:28074
UUID:
uuid:fde25e44-187c-4e27-b6ab-260e166cad9e
Local pid:
pubs:28074
Source identifiers:
28074
Deposit date:
2012-12-19

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