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Journal article

The EJC binding and dissociation activity of PYM is regulated in Drosophila

Abstract:

In eukaryotes, RNA processing events in the nucleus influence the fate of transcripts in the cytoplasm. The multi-protein exon junction complex (EJC) associates with mRNAs concomitant with splicing in the nucleus and plays important roles in export, translation, surveillance and localization of mRNAs in the cytoplasm. In mammalian cells, the ribosome associated protein PYM (HsPYM) binds the Y14-Mago heterodimer moiety of the EJC core, and disassembles EJCs, presumably during the pioneer round...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1004455

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Pubs id:
pubs:505602
UUID:
uuid:fdd814ef-0423-4db2-946f-81354e4ea80a
Local pid:
pubs:505602
Source identifiers:
505602
Deposit date:
2015-01-29

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