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Thesis

Analysis of the roles of CDK1 and PP1 in the regulation of chromosome segregation

Abstract:

Accurate chromosome segregation in mitosis is essential for the faithful inheritance of genetic material. The Spindle Assembly Checkpoint (SAC) ensures genomic stability is maintained by monitoring the attachment of chromosomes to the mitotic spindle and preventing erroneous chromosome segregation. Checkpoint regulation is coordinated by the opposing activities of kinases and phosphatases. CDK1 is the major mitotic kinase required for mitotic entry and activation of the SAC. In particular, CD...

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Division:
MSD
Role:
Author

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Supervisor
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Name:
Wellcome Trust
Funder identifier:
http://dx.doi.org/10.13039/100010269
Programme:
4-year Wellcome Trust Studentship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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