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Journal article

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukaemia.

Abstract:

Somatic genetic abnormalities are initiators and drivers of disease and have proven clinical utility at initial diagnosis. However, the genetic landscape and its clinical utility at relapse is less well understood and has not been studied comprehensively. We analysed cytogenetic data from 427 children with relapsed B-cell precursor ALL treated on the international trial, ALLR3. Also we screened 238 patients with a marrow relapse for selected copy number alterations (CNA) and mutations. Cytoge...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood-2016-03-704973

Authors


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Funding agency for:
Love, S
Grant:
C5529/A16895
Leukaemia and Lymphoma Research More from this funder
Cancer Research UK More from this funder
Sporting Chance Cancer Foundation More from this funder
National Health and Medical Research Council Australia More from this funder
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Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
128
Issue:
7
Pages:
911-922
Publication date:
2016-05-26
Acceptance date:
2016-05-19
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
625034
Language:
English
Keywords:
Pubs id:
pubs:625034
UUID:
uuid:fdd675bf-31fa-4100-a26e-81a2e922d519
Local pid:
pubs:625034
Deposit date:
2016-08-23

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