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Copy number variations in “classical” obesity candidate genes are not frequently associated with severe early-onset obesity in children

Abstract:
Background: Obesity is genetically heterogeneous and highly heritable, although polymorphisms explain the phenotype in only a small proportion of obese children. We investigated the presence of copy number variations (CNVs) in “classical” genes known to be associated with (monogenic) early-onset obesity in children. Methods: In 194 obese Caucasian children selected for early-onset and severe obesity from our obesity cohort we screened for deletions and/or du... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1515/jpem-2016-0435

Authors


Windholz, J More by this author
Schlicke, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Grant:
for the Clinical Research Center “Obesity Mechanisms” CRC1052/1 C05
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Grant:
(FP7/2007-2013) Beta-JUDO n° 279153; LIFE Child (Leipzig Research Center for Civilization Diseases, Universität Leipzig)
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Grant:
LIFE Child (Leipzig Research Center for Civilization Diseases, Universität Leipzig)
Publisher:
De Gruyter Publisher's website
Journal:
Journal of Pediatric Endocrinology and Metabolism Journal website
Volume:
30
Issue:
5
Pages:
507-515
Publication date:
2017-04-28
Acceptance date:
2017-03-06
DOI:
EISSN:
2191-0251
ISSN:
0334-018X
Pubs id:
pubs:697128
URN:
uri:fdd19289-eec8-437b-910c-2ea6073cb228
UUID:
uuid:fdd19289-eec8-437b-910c-2ea6073cb228
Local pid:
pubs:697128

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