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Directional control of a processive molecular hopper

Abstract:

Intrigued by the potential of nanoscale machines, scientists have long attempted to control molecular motion. We monitored the individual 0.7-nanometer steps of a single molecular hopper as it moved in an electric field along a track in a nanopore controlled by a chemical ratchet. The hopper demonstrated characteristics desired in a moving molecule: defined start and end points, processivity, no chemical fuel requirement, directional motion, and external control. The hopper was readily functi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1126/science.aat3872

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Subgroup:
Chemical Biology
Oxford college:
Brasenose College
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Chemical Biology
Oxford college:
Exeter College
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Chemical Biology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Chemical Biology
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
361
Issue:
6405
Pages:
908-912
Publication date:
2018-08-31
Acceptance date:
2018-06-21
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pubs id:
pubs:912038
URN:
uri:fdccbbca-cd54-4f56-83d7-22b5c9247fc6
UUID:
uuid:fdccbbca-cd54-4f56-83d7-22b5c9247fc6
Local pid:
pubs:912038

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