Journal article
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
- Abstract:
-
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, perhaps most, sporadic colon cancers. By screening with single-strand conformation polymorphism analysis we identified several mutations in a small region of the APC gene in both FAP and sporadic cancers. These mutations were either point mutations or small deletions or insertions causing frameshifts, and all generated stop codons. One 5 base-pair deletion was found in a sporadic colon tumour, ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/0140-6736(92)92169-g
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Authors
Bibliographic Details
- Journal:
- Lancet
- Volume:
- 340
- Issue:
- 8820
- Pages:
- 626-630
- Publication date:
- 1992-09-01
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- Source identifiers:
-
487618
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:487618
- UUID:
-
uuid:fdc81073-f785-43fa-acea-04c2d0ee944d
- Local pid:
- pubs:487618
- Deposit date:
- 2014-10-29
Terms of use
- Copyright date:
- 1992
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