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Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.

Abstract:

Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, perhaps most, sporadic colon cancers. By screening with single-strand conformation polymorphism analysis we identified several mutations in a small region of the APC gene in both FAP and sporadic cancers. These mutations were either point mutations or small deletions or insertions causing frameshifts, and all generated stop codons. One 5 base-pair deletion was found in a sporadic colon tumour, ...

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Publication status:
Published

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Journal:
Lancet More from this journal
Volume:
340
Issue:
8820
Pages:
626-630
Publication date:
1992-09-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Language:
English
Keywords:
Pubs id:
pubs:487618
UUID:
uuid:fdc81073-f785-43fa-acea-04c2d0ee944d
Local pid:
pubs:487618
Source identifiers:
487618
Deposit date:
2014-10-29

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