- Abstract:
-
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, perhaps most, sporadic colon cancers. By screening with single-strand conformation polymorphism analysis we identified several mutations in a small region of the APC gene in both FAP and sporadic cancers. These mutations were either point mutations or small deletions or insertions causing frameshifts, and all generated stop codons. One 5 base-pair deletion was found in a sporadic colon tumour, ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/0140-6736(92)92169-g
-
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- Journal:
- Lancet
- Volume:
- 340
- Issue:
- 8820
- Pages:
- 626-630
- Publication date:
- 1992-09-05
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- URN:
-
uuid:fdc81073-f785-43fa-acea-04c2d0ee944d
- Source identifiers:
-
487618
- Local pid:
- pubs:487618
- Language:
- English
- Keywords:
- Copyright date:
- 1992
Journal article
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
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