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Alteration of water structure by peptide clusters revealed by neutron scattering in the small-angle region (below 1 A(-1)).

Abstract:

Solution scattering of neutrons and x-rays can provide direct information on local interactions of importance for biomolecular folding and structure. Here, neutron scattering experiments are combined with molecular-dynamics simulation to interpret the scattering signal of a series of dipeptides with varying degrees of hydrophobicity (GlyAla, GlyPro, and AlaPro) in concentrated aqueous solution (1:20 solute/water ratio) in which the peptides form large segregates (up to 50-60 amino acids). Two...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2012.08.010

Authors


Daidone, I More by this author
Iacobucci, C More by this author
McLain, SE More by this author
Journal:
Biophysical journal
Volume:
103
Issue:
7
Pages:
1518-1524
Publication date:
2012-10-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:fdbfe67b-bce1-4248-bdde-503761129acb
Source identifiers:
342613
Local pid:
pubs:342613

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