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Transmembrane peptide NB of influenza B: a simulation, structure, and conductance study.

Abstract:

The putative transmembrane segment of the ion channel forming peptide NB from influenza B was synthesized by standard solid-phase peptide synthesis. Insertion into the planar lipid bilayer revealed ion channel activity with conductance levels of 20, 61, 107, and 142 pS in a 0.5 M KCl buffer solution. In addition, levels at -100 mV show conductances of 251 and 413 pS. A linear current-voltage relation reveals a voltage-independent channel formation. In methanol and in vesicles the peptide appe...

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Publication status:
Published

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Publisher copy:
10.1021/bi001000e

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Journal:
Biochemistry More from this journal
Volume:
39
Issue:
41
Pages:
12708-12716
Publication date:
2000-10-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960

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