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Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin

Abstract:

Objective: A major site of action for the atheroprotective drug nicotinic acid (NA) is adipose tissue, via the G-protein-coupled receptor, GPR109A. Since, adipose tissue is an active secretory organ that contributes both positively and negatively to systemic inflammatory processes associated with cardiovascular disease, we hypothesized that NA would act directly upon adipocytes to alter the expression of pro-inflammatory chemokines, and the anti-inflammatory adipokine adiponectin. Methods and...

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Journal:
Atherosclerosis More from this journal
Volume:
209
Issue:
1
Pages:
89-95
Publication date:
2010-03-01
DOI:
ISSN:
0021-9150
Language:
English
Keywords:
Pubs id:
pubs:106102
UUID:
uuid:fda44a65-aac9-44cb-bd68-12b576fe3d95
Local pid:
pubs:106102
Source identifiers:
106102
Deposit date:
2012-12-19

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