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Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin

Abstract:

Objective: A major site of action for the atheroprotective drug nicotinic acid (NA) is adipose tissue, via the G-protein-coupled receptor, GPR109A. Since, adipose tissue is an active secretory organ that contributes both positively and negatively to systemic inflammatory processes associated with cardiovascular disease, we hypothesized that NA would act directly upon adipocytes to alter the expression of pro-inflammatory chemokines, and the anti-inflammatory adipokine adiponectin. Methods and...

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Journal:
Atherosclerosis
Volume:
209
Issue:
1
Pages:
89-95
Publication date:
2010-03-05
DOI:
ISSN:
0021-9150
URN:
uuid:fda44a65-aac9-44cb-bd68-12b576fe3d95
Source identifiers:
106102
Local pid:
pubs:106102

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