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Chromosomal gene movements reflect the recent origin and biology of therian sex chromosomes

Abstract:

Mammalian sex chromosomes stem from ancestral autosomes and have substantially differentiated. It was shown that X-linked genes have generated duplicate intronless gene copies (retrogenes) on autosomes due to this differentiation. However, the precise driving forces for this out-of-X gene "movement" and its evolutionary onset are not known. Based on expression analyses of male germ-cell populations, we here substantiate and extend the hypothesis that autosomal retrogenes functionally compensa...

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Authors


Potrzebowski, L More by this author
Vinckenbosch, N More by this author
Marques, AC More by this author
Chalmel, F More by this author
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Journal:
PLoS Biology
Volume:
6
Issue:
4
Pages:
709-716
Publication date:
2008-04-05
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
URN:
uuid:fd9fee67-597a-4cba-9b33-7660b7e0a8d9
Source identifiers:
345433
Local pid:
pubs:345433
Language:
English

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