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Journal article

The transcription factor Nrf2 protects angiogenic capacity of endothelial colony-forming cells in high-oxygen radical stress conditions

Abstract:

Background. Endothelial colony forming cells (ECFCs) have shown a promise in tissue engineering of vascular constructs, where they act as endothelial progenitor cells. After implantation, ECFCs are likely to be subjected to elevated reactive oxygen species (ROS). The transcription factor Nrf2 regulates the expression of antioxidant enzymes in response to ROS. Methods. Stable knockdown of Nrf2 and Keap1 was achieved by transduction with lentiviral shRNAs; activation of Nrf2 was induced by incu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1155/2017/4680612

Authors


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Role:
Author
ORCID:
0000-0002-7818-620X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
Publisher:
Hindawi Publishing Corporation
Journal:
Stem Cells International More from this journal
Volume:
2017
Pages:
4680612
Publication date:
2017-05-01
Acceptance date:
2017-04-16
DOI:
EISSN:
1687-9678
ISSN:
1687-966X
Keywords:
Pubs id:
pubs:701749
UUID:
uuid:fd9d3e07-ef0e-4d33-aa44-4b245da85053
Local pid:
pubs:701749
Source identifiers:
701749
Deposit date:
2018-03-06

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