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Brain imaging reveals that engagement of descending inhibitory pain pathways in healthy women in a low endogenous estradiol state varies with testosterone

Abstract:

The combined oral contraceptive pill (COCP) has been implicated in the development of a number of chronic pain conditions. Modern COCP formulations produce a low endogenous estradiol, low progesterone environment similar to the early follicular phase of the natural menstrual cycle, with a variable effect on serum androgen levels. We used behavioural measures and functional magnetic resonance imaging to investigate the response to experimental thermal stimuli in healthy women, in both a natura...

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Publisher copy:
10.1016/j.pain.2012.11.016

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Pain More from this journal
Volume:
154
Issue:
4
Pages:
515-524
Publication date:
2013-04-01
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
Language:
English
Keywords:
Pubs id:
pubs:395277
UUID:
uuid:fd936313-27bf-4e82-9af0-85dbd21fd450
Local pid:
pubs:395277
Source identifiers:
395277
Deposit date:
2013-11-16

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