Journal article icon

Journal article

The retinoblastoma protein modulates Tbx2 functional specificity.

Abstract:

Tbx2 is a member of a large family of transcription factors defined by homology to the T-box DNA-binding domain. Tbx2 plays a key role in embryonic development, and in cancer through its capacity to suppress senescence and promote invasiveness. Despite its importance, little is known of how Tbx2 is regulated or how it achieves target gene specificity. Here we show that Tbx2 specifically associates with active hypophosphorylated retinoblastoma protein (Rb1), a known regulator of many transcrip...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1091/mbc.e09-12-1029
Journal:
Molecular biology of the cell More from this journal
Volume:
21
Issue:
15
Pages:
2770-2779
Publication date:
2010-08-01
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
Language:
English
Keywords:
Pubs id:
pubs:60455
UUID:
uuid:fd9038bc-8959-4148-a497-0d6a91215f87
Local pid:
pubs:60455
Source identifiers:
60455
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP