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Details of a prospective protocol for a collaborative meta-analysis of individual participant data from all randomized trials of intravenous rt-PA vs. control: statistical analysis plan for the Stroke Thrombolysis Trialists' Collaborative meta-analysis.

Abstract:

RATIONALE: Thrombolysis with intravenous alteplase is both effective and safe when administered to particular types of patient within 4·5 hours of having an ischemic stroke. However, the extent to which effects might vary in different types of patient is uncertain. AIMS AND DESIGN: We describe the protocol for an updated individual patient data meta-analysis of trials of intravenous alteplase, including results from the recently reported third International Stroke Trial, in which a wide range...

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Publisher copy:
10.1111/ijs.12040
Journal:
International journal of stroke : official journal of the International Stroke Society More from this journal
Volume:
8
Issue:
4
Pages:
278-283
Publication date:
2013-06-01
DOI:
EISSN:
1747-4949
ISSN:
1747-4930

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