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Journal article

Opioids stimulate growth hormone (GH) release in man independently of GH-releasing hormone.

Abstract:

The Met-enkephalin analog DAMME [D-Ala2,MePhe4-Met-enkephalin-(o)-o1, FK 33-824] can stimulate GH secretion in man. In this study we investigated the effects of the guanyl derivative of DAMME (G-DAMME) on the serum GH response to an analog of GHRH in normal men. GHRH-(1-29)NH2 and G-DAMME each induced a rise in serum GH, and the increase was greater when both were given together. Since the GHRH-(1-29)NH2 dose (100 micrograms) used was a maximally stimulatory one, these results suggest that th...

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Publication status:
Published

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Publisher copy:
10.1210/jcem-69-2-356

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Journal of clinical endocrinology and metabolism More from this journal
Volume:
69
Issue:
2
Pages:
356-358
Publication date:
1989-08-01
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Language:
English
Keywords:
Pubs id:
pubs:138742
UUID:
uuid:fd8aca5b-ed3e-4c08-b226-7480bbd586aa
Local pid:
pubs:138742
Source identifiers:
138742
Deposit date:
2012-12-19

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