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Dissecting the actin cortex density and membrane-cortex distance in living cells by super-resolution microscopy

Abstract:

Nanoscale spacing between the plasma membrane and the underlying cortical actin cytoskeleton profoundly modulates cellular morphology, mechanics, and function. Measuring this distance has been a key challenge in cell biology. Current methods for dissecting the nanoscale spacing either limit themselves to complex survey design using fixed samples or rely on diffraction-limited fluorescence imaging whose spatial resolution is insufficient to quantify distances on the nanoscale. Using dual-color...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1088/1361-6463/aa52a1

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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
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Author
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Department:
Oxford, MSD, RDM
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Author
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Department:
Christ Church
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Author
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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
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Author
Wolfson Foundation More from this funder
Publisher:
Institute of Physics Publisher's website
Journal:
Journal of Physics D: Applied Physics Journal website
Volume:
50
Issue:
6
Publication date:
2017-01-05
Acceptance date:
2016-12-08
DOI:
ISSN:
1361-6463 and 0022-3727
Pubs id:
pubs:679621
URN:
uri:fd858caa-b120-44d4-97c0-87843640d04d
UUID:
uuid:fd858caa-b120-44d4-97c0-87843640d04d
Local pid:
pubs:679621

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