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Cytolytic T-cell response to the PASD1 cancer testis antigen in patients with diffuse large B-cell lymphoma.

Abstract:

The identification of immunogenic cancer testis antigens (CTAs) as immunotherapeutic targets represents one approach to improve treatment options for diffuse large B-cell lymphoma (DLBCL). We previously identified PASD1 [PAS (Per ARNT Sim) domain containing 1 (PASD1)], a DLBCL-associated CTA that was expressed in a range of hematopoietic malignancies. The aim of the present study was to investigate the presence of a cytotoxic T-cell (CTL) response to PASD1 in DLBCL patients. A significant gam...

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Authors


Ait-Tahar, K More by this author
Liggins, AP More by this author
Collins, GP More by this author
Campbell, A More by this author
Barnardo, M More by this author
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Journal:
British journal of haematology
Volume:
146
Issue:
4
Pages:
396-407
Publication date:
2009-08-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:fd814add-097b-4728-8abd-c7f4704f4250
Source identifiers:
246565
Local pid:
pubs:246565

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