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Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

Abstract:

Radiotherapy is a major treatment modality used to treat muscle-invasive bladder cancer, with patient outcomes similar to surgery. However, radioresistance is a significant factor in treatment failure. Cell-free extracts of muscle-invasive bladder tumors are defective in nonhomologous end-joining (NHEJ), and this phenotype may be used clinically by combining radiotherapy with a radiosensitizing drug that targets homologous recombination, thereby sparing normal tissues with intact NHEJ. The re...

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Publication status:
Published

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Authors


Groselj, B More by this author
Knowles, MA More by this author
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Journal:
Cancer research
Volume:
73
Issue:
5
Pages:
1611-1620
Publication date:
2013-03-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:fd6ee70a-2cdb-41d6-979f-43836606b95b
Source identifiers:
374277
Local pid:
pubs:374277

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