- Abstract:
-
Radiotherapy is a major treatment modality used to treat muscle-invasive bladder cancer, with patient outcomes similar to surgery. However, radioresistance is a significant factor in treatment failure. Cell-free extracts of muscle-invasive bladder tumors are defective in nonhomologous end-joining (NHEJ), and this phenotype may be used clinically by combining radiotherapy with a radiosensitizing drug that targets homologous recombination, thereby sparing normal tissues with intact NHEJ. The re...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1158/0008-5472.can-12-1170
-
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- Journal:
- Cancer research
- Volume:
- 73
- Issue:
- 5
- Pages:
- 1611-1620
- Publication date:
- 2013-03-05
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- URN:
-
uuid:fd6ee70a-2cdb-41d6-979f-43836606b95b
- Source identifiers:
-
374277
- Local pid:
- pubs:374277
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Imatinib radiosensitizes bladder cancer by targeting homologous recombination.
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